The power of gene expression
The Pathwork® Tissue of Origin Test measures the expression of more than 1500 genes present in a tissue sample and generates the tumor's gene expression profile. This profile is then compared to those of 15 known tissues, representing more than 60 morphologies. An objective, probability-based Similarity Score is provided for each of the 15 potential tissue types, enabling each tissue type to be ruled in or ruled out.
Supported by extensive analytical and clinical validation data
- In a study of 487 metastatic and poorly differentiated and undifferentiated tumors already identified by current methodologies, the Pathwork Tissue of Origin Test demonstrated a sensitivity of 89 percent and a specificity of 99 percent. (Monzon FA, Lyons-Weiler M, Buturovic LJ, et al. Association for Molecular Pathology Annual Meeting, 2007, Abstract #ST02)
- In a cross-laboratory comparison study of 60 metastatic and poorly differentiated and undifferentiated tissue specimens, the test demonstrated an average 94 percent overall concordance across four laboratories. (CI Dumur, et al. J Mol Diagn. 2008;10:67-77)
Now available through Pathwork Diagnostics Laboratory
The Pathwork Tissue of Origin Test is now available to oncologists and pathologists through the CLIA-certified Pathwork® Diagnostics Laboratory. Download our test information sheet.
