Clinical Information
Publications
For a printer-friendly bibliography of abstracts to all Tissue of Origin related publications and posters, click below.
Peer-reviewed Publications
Clinical Verification of the performance of the Pathwork Tissue of Origin Test. CI Dumur, CE Fuller, TL Blevins, JC Schaum, DS Wilkinson, CT Garrett, CN Powers. Am J Clin Pathol 2011;136:924-933
Potential Clinical Utility of Gene-Expression profiling in Identifying tumors of uncertain origin. M Laouri, M Halks-Miller, WE Henner, JS Nystrom. Personalized Medicine, (2011) 8 (6), 615-622
Gene-Expression assays and personalized cancer care: Tissue of Origin for Cancer of Unknown primary origin.H Takei, FA Monzon. Personalized Medicine (2011) 8(4), 429–436
Identification of Tissue of Origin in body fluid specimens with a gene expression microarray assay. GA Stancel, D Coffey, K Alvarez, M Halks-Miller, A Lal, D Mody, T Koen, T Fairley, FA Monzon. Cancer Cytopathology, Jun 29, 2011
Molecular Tumor Profiling in the Diagnosis of Patients with Carcinoma of Unknown Primary Site: Retrospective Evaluation of Gene Microarray Assay, J Hainsworth, R Pillai, DW Henner, M Halks-Miller, C Lane, FA Greco. J Molec Bio and Diagn, June 27, 2011
Unique patterns of metastases in common and rare types of malignancies, SPL Leong, EK Nakakura, R Pollock, MA Choti, DL Morton, WD Henner, A Lal, R Pillai, OH Clark, B Cady. Journal of Surgical Oncology, 103: 607-614. doi: 10.1002/jso.21841
Gene expression profiling from formalin-fixed, paraffin-embedded tssue for tumor diagnosis, JP Grenert, A Smith, W Ruan, R Pillai, AH Wu. Clin Chim Acta, 412 (2011) 1462-1464
Validation and Reproducibility of a Microarray-Based Gene Expression Test for Tumor Identification in Formalin-Fixed, Paraffin-Embedded Specimens, R Pillai, R Deeter, CT Rigl, JS Nystrom, M Halks-Miller, L Buturovic, WD Henner. J Molec Diag 13 (2011) pp. 48-56
Gene expression profiles help identify the Tissue of Origin for metastatic brain cancers, A Wu, J Drees, H Wang, S VandenBerg, A Lal, WD Henner, R Pillai. Diag Pathol, 2010, 5:26
Diagnosis of metastatic neoplasms: molecular approaches for identification of tissue of origin, FA Monzon, TJ Koen. Arch Pathol Lab Med 2010 Feb: 134 (2):216-24
Identification of tissue of origin in carcinoma of unknown primary with a microarray-based gene expression test, FA Monzon, F Medieros, M Lyons-Weiler, WD Henner, Diagn Pathol. 2010 Jan 13;5:3
Diagnosis of uncertain primary tumors with the Pathwork Tissue of Origin Test, FA Monzon, CI Dumur, Expert Review of Molecular Diagnostics, January 2010, Vol. 10, No. 1, Pages 17-25
Determining Tissue of Origin for Metastatic Cancers; Meta-Analysis and Literature Review of Immunohistochemistry Performance, GG Anderson, L Weiss. Applied Immunohistochemistry & Molecular Morphology: January 2010 - Volume 18 - Issue 1 - pp 3-8
Multicenter Validation of a 1,550-Gene Expression Profile for Identification of Tumor Tissue of Origin. FA Monzon, M Lyons-Weiler, LJ Buturovic, CT Rigl, WD Henner, C Sciulli, CI Dumur, F Medeiros, GG Anderson. J Clin Oncol. 2009;27:1-13; doi:10.1200/JCO.2008.17.9762.
Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. CI Dumur, M Lyons-Weiler, C Sciulli, CT Garrett, I Schrijver, TK Holley, J Rodriguez-Paris, JR Pollack, JL Zehnder, M Price, JM Hagenkord, CT Rigl, LJ Buturovic, GG Anderson, FA Monzon. J Mol Diagn. 2008;10(1):67-77.
Abstracts & Posters
Cost- effectiveness of gene-expression profiling for tumor-site origin. J Hornberger, I Degtiar, H Gutierrez, A Shewade, WD Henner, S Becker, S Raab AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy, and Personalized Medicine, January 10, 2012, San Diego, CA
Utility of gene-expression profiling for reporting difficutl to diagnose cancers. M Pollen, G Wellman, M Lowery-Nordberg. Association for Molecular Pathologists Annual Meeting, November 17-19, 2011, Grapevine, TX
A gene expression profile test for the differential diagnosis of ovarian versus endometrial cancers. A Lal, R Panos, M Marjanovic, M Walker, E Fuentes, WD Henner, L Buturovic, M Halks-Miller. Cancer Cytogenomics Microarray Consortium Summer Meeting Abstract Presentation, Aug 8, 2011, Chicago, IL
Clinical utility of gene-expression profiling for tumor site origin, H.R. Gutierrez, J.C. Hornberger, G.R. Varadhachary, R.J. Hornberger, W.D. Henner, S. Becker, M. Walker, M. Amin, J.S. Nystrom. J Clin Oncol 29: 2011 (suppl; abstr e21093)
Performance of a Gene Expression Microarray Assay to Determine Tissue of Origin in Cytology Body Fluid Specimens, F.A. Monzon, G.A. Stancel, K. Alvarez, T. Fairley, D. Mody, D. Coffey. Poster presented at USCAP, February 26 - March 4, San Antonio, TX
Effect of a gene expression-based Tissue of Origin Test on patient management for difficult-to-diagnose primary cancers, J. Hornberger, M. Amin, G. Varadhachary, W.D. Henner, J.S. Nystrom. Poster presented at ASCO GI, January 22, 2011, San Francisco, CA
Gene expression profiling from FFPE tissue for tumor diagnosis, J.P. Grenert, R. Pillai, A.H.B. Wu. Poster presented at the Association for Molecular Pathology Annual Meeting, November 17 - 20, 2010, San Jose, CA
Molecular Tumor Profiling in the Diagnosis of Patients with Carcinoma of Unknow Primary (CUP): Retrospective Evaluation of the Tissue of Origin Test (Pathwork Diagnostics), J. Hainsworth, D. Henner, R. Pillai, F. Anthony Greco. Poster presented at ASCO-NCI-EORTC, October 18 - 20, 2010, Hollywood, FL
Impact of a Gene Expression-Based Tissue of Origin Test on Diagnosis and Recommendations for First-Line Chemotherapy, M. Laouri, J.S. Nystrom, M. Halks-Miller, W.D. Henner. Poster presented at ASCO, June 4 - 8, 2010, Chicago, IL
Evaluation of a Gene Expression Microarray Assay to Determine Tissue of Origin in Body Fluid Specimens, G.A. Stancel, D. Coffey, D. Mody, K. Alvarez, T. Koen, T. Fairley, F.A. Monzon. Poster presented at USCAP, March 20 - 26, 2010, Washington, D.C.
Microarray-Based Gene Expression Assay for Identification of Primary Site Using Formalin-Fixed Paraffin-Embedded (FFPE) Tissue, R. Pillai, R. Deeter, L. Buturovic, J.S. Nystrom, M. Halks-Miller, D. Henner. Poster presented at ASCO GI, January 22 - 24, 2010, Orlando, FL
Gene Expression Profiles Help Identify the Tissue of Origin for Metastatic Brain Cancers, AHB Wu, JC Drees, HP Wang, SB VandenBerg, A Lal, WD Henner, R Pillai. Poster presented at AMP, November 19 - 22, 2009, Kissimmee, FL
A Microarray-Based Gene Expression Test as an Aid to Tumor Diagnosis Using Formalin-Fixed Paraffin-Embedded (FFPE) Specimens, R. Pillai, R. Deeter, C.T. Rigl, M. Halks-Miller, L. Buturovic, D. Henner; Pathwork Diagnostics. Poster presented at CAP, October 11 - 14, 2009, Washington, D.C.
Validation of a microarray-based gene expression test for tumors with uncertain origins using formalin-fixed paraffin-embedded (FFPE) specimens. R. Pillai, R. Deeter, C.T. Rigl, M.Halks-miller, W.D Henner, L.Buturovic; Pathwork Diagnostics. J Clin Oncol. 2009;27 (suppl; abstr e20015).
Use of a microarray-based 1550-gene expression profile in the diagnosis of carcinoma of unknown primary (CUP). Monzon FA, Medeiros F , Henner W. Poster presented at ASCO 2009 Gastrointestinal Cancers Symposium; January 15-17, 2009; San Francisco CA.
A meta-analysis of the use of IHC testing in metastatic disease: the need for integration of new technologies. GG Anderson, LM Weiss. Poster presented at the ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer; Oct 30 - Nov 1, 2008; Hollywood, FL.
Assessing the impact of tumor devitalization time on gene expression-based tissue of origin testing. CI Dumur, A Ladd, A Ferreira-Gonzalez, CT Rigl, RA Deeter, DS Wilkinson, CN Powers, CT Garrett. Poster presented at the Association for Molecular Pathology; October 29 - November 2, 2008; Grapevine, TX.
Gene expression microarray-based diagnostic test may identify primary tumor site in patients with carcinoma of unknown primary (CUP). F Medeiros, et al. Poster presented at the Association for Molecular Pathology; October 29 - November 2, 2008; Grapevine, TX.
Clinical verification of the Pathwork Tissue of Origin Test on poorly differentiated metastases. CI Dumur, et al. Poster presented at the Association for Molecular Pathology; October 29 - November 2, 2008; Grapevine, TX.
Ovarian mucinous neoplasms: Can gene expression microarray-based technology distinguish primary versus metastatic tumors? F Medeiros, KC Halling, CP Kolbert, F Rakhshan Rohakhtar, TM Kane Lindgren, MJ Wilson, CM Rendler, MP Goetz, DA Bell.
Poster presented at the International Congress of the International Academy of Pathology; October 12 - 17, 2008; Athens, Greece.
A gene expression microarray-based diagnostic test applied to patients with carcinoma of unknown primary (CUP). F Medeiros, CP Kolbert, F Rakshan Rohakhtar, T Kane Lindgren, MJ Wilson, CT Rigl, MP Goetz, WD Henner, KC Halling. American Society of Clinical Oncology; May 30-June 3, 2008; Chicago, IL; Abstract 22123.
Validation of a gene expression-based tissue of origin test applied to poorly differentiated and undifferentiated cancers. FA Monzon, CI Dumur, M Lyons-Weiler, CM Sciulli, CT Garrett, JM Hagenkord, LJ Buturovic, R Deeter, SH Becker, CT Rigl, GG Anderson. Poster presented at the annual meeting for the Association for Molecular Pathology; November 7-10, 2007; Los Angeles, CA.
Analytical performance of a microarray-based expression test to determine tissue of origin in uncertain primary cancers. CI Dumur, M Lyons-Weiler, CT Garrett, TK Holley, I Schrijver, J Rodriguez-Paris, JR Pollack, JL Zehnder, CM Sciulli, JM Hagenkord, M Price, CT Rigl, LJ Buturovic, GG Anderson, FA Monzon. Poster presented at the annual meeting of the Association for Molecular Pathology; November 7-10, 2007; Los Angeles, CA.
A gene expression-based assay for identifying tissue of origin: application to metastatic lesions in the brain. S Cheshier, S Chang, LJ Buturovic, CT Rigl, WD Henner, GG Anderson. Poster presented at the annual meeting of the Society for Neuro-Oncology, November 15-18, 2007; Dallas, TX; Abstract GE-15.
On the optimal number of gene expression mMarkers for tissue of origin cancer diagnostics. LJ Buturovic. Poster presented at the annual meeting for the American Association for Cancer Research; September 17-20, 2007; Atlanta, GA; B4.
Incidence, costs of care and survival of medicare beneficiaries diagnosed with carcinoma of unknown primary origin. KB Tong, HB Hubert, B Santry, AJ Layton, SH Becker, GG Anderson. Poster presented at the annual meeting of the American Society of Clinical Oncology; June 2-6, 2006; Atlanta, GA. Abstract.
Trade Journals
TechSectors - Diagnostics: Genomics-based tests can help diagnose uncertain cancers. WD Henner. Oncology Net Guide. 2008;9(7):32.
Identifying tumors of uncertain origin. SH Becker. Advance for Administrators of the Laboratory. 2006;15(11):58
Presentations
A Gene Expression Profile Test for the Differential Diagnosis of Ovarian Versus Endometrial Cancers, presented by A Lal. Cancer Cytogenomics Microarray Consortium Summer Meeting, August 8, 2011, Chicago, IL
ASCO-NCI-EORTC immunohistochemistry meta-analysis, 2008 Molecular Markers