Pathwork Diagnostics

Initial presentation:
A 41 year old asymptomatic, pre-menopausal, non-smoking female who presents with a 3 cm left axillary mass and no breast abnormalities.

Work up:

Initial treatment:
Carboplatin and Taxol®

Pathwork® Tissue of Origin Test ordered.

“Chemotherapy needs to cover both breast and lung.”

Results - Tissue of Origin Test:
Interpretation from Pathwork Diagnostics’ pathologist: “High probability of breast cancer. The Tissue of Origin Test has effectively ruled out a derivation from the 12 tissue types with scores ranging from 4.9 to 0.2, as Similarity Scores below 5 indicate a greater than 99% probability of that tissue type not being the correct tissue of origin. Specifically, Non-small Cell Lung, with a Similarity Score of 3.0, is excluded by the Tissue of Origin Test.”

Post Tissue of Origin Test treatment:

• Chemoprevention with tamoxifen indicated to prevent contra-lateral breast cancer
• Carboplatin and Taxol changed to dose dense AC/Taxol
• Testing for familial predisposition to breast and ovarian cancer indicated (BRCA1/BRCA2)
• Axillary node dissection performed; 2/15 nodes positive for adenocarcinoma (consistent
• with results of the Pathwork Tissue of Origin Test)—potentially curative surgery

“All is going well for my patient and, thanks to the Pathwork Diagnostics assay, we have greater confidence that not only is she getting the appropriate treatment, she has a good chance of being cured.”
-- Dr.C.K., Austin, TX